Agenda

Sunday, November 30th
6:00pm - 8:00pm Networking Event - Three Notch'd Brewing Company. Please join anytime; food and drink for purchase in a reserved space for IMAT investigators and UVA invitees. 520 2nd St SE, Charlottesville, VA 22902

Monday, December 1st
9:00am - 9:15am Introduction/Welcome
9:15am - 9:45am Thomas P. Loughran Jr., MD, Director, UVA Comprehensive Cancer Center UVACCC Welcome and Overview
9:45am - 10:00am Jarrod Marto, PhD, University of Virginia UVA History of Innovation and Highlights
Session Preclinical Screening
Moderated By: Nan Liu, PhD, Boston College
10:00am - 10:15am Guillem Pratx, PhD, Stanford University A Novel Assay to Individualize Resensitization of Iodine-Refractory Thyroid Cancer
10:15am - 10:30am Soma Dhakal, PhD, Virginia Commonwealth University Towards High-Confidence Single-Molecule Detection of miRNA Cancer Biomarkers
10:30am - 10:45am Joshua Labaer, MD, PhD, Arizona State University Multiplex In-Solution Protein Array (MISPA) for High-Throughput, Quantitative, Early Profiling of Pathogen-Induced Head and Neck Cancer
10:45am - 11:00am Coffee Break
11:00am - 11:15am Nir Hacohen, PhD, Harvard University RNA-Encoded Large-Scale Nanobody Libraries for In Vitro Screening Against Tumor Targets
11:15am - 11:30am Kate Meyer, PhD, Duke University A High-Throughput Screening Platform to Discover RNA Methylation Inhibitors
11:30am - 11:45am Flash Talks
• Yanxiang Deng, PhD, University of Pennsylvania: Spatially Resolved Multi-Omits Sequencing of FFPE Tissues at a Cellular Level;
• Jesse Boehm, PhD, MIT: Label-Free Morphological Profiling Enables Rapid Ex Vivo Evaluation of Anti-Cancer Drug Sensitivity in Gastroesophogeal Ascites;
• Tania (Tali) Konry, PhD, Northeastern University: Development of a Microfluidic MM-on-a-Chip Platform to Model Immunotherapy Resistance in a Hypoxic Tumor Microenvironment.
11:45am - 1:15pm Lunch
Session Clinical Session 1
Moderated By: Matthew Shorey, PhD, Houston Methodist
1:15pm - 1:30pm Christopher M. Counter, PhD, Duke University KRAS Mutations in Whole Body Blood by Error-Corrected Sequencing
1:30pm - 1:45pm Steven A. Soper, PhD, the University of Kansas Molecular Sub-Typing Breast Cancer Patients Using a Liquid Biopsy
1:45pm - 2:00pm Eric J. Duncavage, MD, Washington University in St. Louis A Rapid and Comprehensive Approach for Clinical Genomic Profiling in Lung Cancer
2:00pm - 2:15pm David Aaron Issadore, PhD, University of Pennsylvania Combining Machine Learning and Nanofluidic Technology for the Multiplexed Diagnosis of Pancreatic Adenocarcinoma
2:15pm - 2:30pm Jose Javier Bravo-Cordero, PhD, Icahn School of Medicine at Mount Sinai Intersectional Genetics-Based Biosensors for Dormant Cancer Cells
2:30pm - 3:00pm Coffee Break
3:00pm - 3:20pm Xin Ma, PhD, University of Virginia (Guest) Evaluating Invasive Potentials of Pituitary Neuroendocrine Tumors Using High-Resolution Spatial Metabolomics
3:20pm - 3:40pm Kelsey Kubelick, PhD, University of Virginia (Guest) Echoing Immunotherapy — Ultrasound and Photoacoustic Imaging Towards Advanced Cancer Theranostics
3:40pm - 4:10pm Flash Talks
• Amanda Kussrow, PhD, Vanderbilt University: Quantification of Molecular Interactions Across the Matrix Spectrum Enables Cancer Research;
• Alberto Alaya Sarmiento, PhD, Cedars Sinai: Enabling In Vivo Barcoded Single-Cell Multiomics-Compatible Genome-Wide Screens in Personalized Tumor Models Using Defined-Copy Somatic Transgenesis;
• Huiqing (Jane) Zhou, PhD, Boston College: Development of a Directed Evolution Platform for RNA Methyltransferases;
• Matthew Shorey, PhD, Houston Methodist: A Multiplexed High-Throughput Platform to Report Pharmacologic Alteration of Cancer Stem Cell Membrane Potential and Cell Cycle States;
• Esther Mozipo, Stanford University: Tumor Metabolic Profiling by Multiplexed Single-Cell Lipid and mRNA Imaging.
4:10pm - 5:00pm Panel Discussion: Engage, support and cultivate successful team-based efforts
Moderated By: Adrian Shimpi, PhD, University of Virginia 		Panelists: David Kashatus, PhD, Kelly Shaffer, PhD, and Francine Garrett-Bakelman, MD, University of Virginia
5:00pm - 5:25pm Transition - Music Provided by Youth Orchestras of Central Virginia
5:25pm - 6:10pm Poster Session A
6:15pm - 7:00pm Poster Session B

Tuesday, December 2nd
9:00am - 9:10am Organizer updates/housekeeping
Session Clinical Session 2
Moderated By: Zhengyuan Pang, PhD, Scripps Research Institute
9:10am - 9:25am Abraham P. Lee PhD, University of California, Irvine Microfluidic Precision Engineered Artificial Antigen Presenting Cells for Cancer Immunotherapy
9:25am - 9:40am Sidi Chen, PhD, Yale University Advanced Development of Composite Gene Delivery and CAR Engineering Systems
9:40am - 9:55am Venktesh Shirure, PhD, University of California, Davis Microfluidic Technology to Isolate Tumoricidal T Cells from Peripheral Blood
9:55am - 10:10am Tianyi Zheng, PhD, University of Wisconsin-Madison Integrative Multi-Modal Analysis of Collagen Alterations in Cancer Models via SHG and Mid-IR Spectroscopy Imaging
10:10am - 10:25am Yevgeny Brudno, PhD, North Carolina State University Transduction Sponges for Rapid and Accessible CAR T-Cell Prototyping
10:25am - 10:45am Coffee Break
Session Sequencing and Biosensors
Moderated By: Megan Schertzer, PhD, University of Virginia
10:45am - 11:00am Wendy Gordon, PhD, University of Minnesota Twin Cities Engineering Protein Modulators of Notch Activation for T-Cell Immunotherapy
11:00am - 11:15am Hanlee P. Ji, MD, Stanford University Single Cell Modeling of Cancer Mutations
11:15am - 11:30am Rizal Hariadi, PhD, Arizona State University High-Throughput, Purification-Free, and Ultrasensitive Transmembrane Nanosensor Arrays for Digital Counting of MicroRNA Biomarkers of Intact Exosomes
11:30am - 11:50am Kristin Anderson, PhD, University of Virginia (Guest) Engineering Anti-Tumor Immunity to Effectively Treat Solid Tumors
11:50am - 1:20pm Lunch
Session Geospatial and Imaging
Moderated By: Vishal Srikanth, PhD, University of North Carolina
1:20pm - 1:35pm Jonathan Carlson, MD, PhD, Harvard University Bioorthogonal Probe Development for Highly Parallel In Vivo Imaging
1:35pm - 1:50pm Zhengyuan Pang, PhD. Scripps Research Institute Mapping Cellular Targets of Covalent Cancer Drugs in the Entire Mammalian Body
1:50pm - 2:05pm Connor Grady, PhD, University of Michigan Integrated Imaging Tools for Intercellular Chemokine Signalling
2:05pm - 2:20pm Facundo Martin Fernandez, PhD, Georgia Institute of Technology Triboelectric Nanogenerator-Powered Laser Ablation Electrospray Ionization (TENG LAESI) Mass Spectrometry Imaging Ion Source
2:20pm - 2:35pm Peter van Galen, PhD, Harvard University Clonal Analysis of Cancer by Mitochondrial DNA Barcoding
2:35pm - 2:55pm Jinghang Xie, PhD, Universty of Virginia (Guest) From Biospecimens to Living Drugs: Functional T-Cell Imaging to Enhance Tumor Infiltrating Lymphocyte Therapy
2:55pm - 3:10pm Coffee Break
3:10pm - 4:00pm Panel Discussion: Building and Finding Ecosystems for Innovation and Translation
Moderated By: Kelly Crotty, PhD, NCI 		Panelists: Nikki Hastings, PhD, Director, CvilleBioHub, Evan Scott, PhD, Director, NanoSTAR, University of Virginia, and David Chen, MS MBA, Director Coulter Center for Translational Research
Session Protein Engineering and Detection
Moderated By: Reagan Portelance, University of Virginia
4:00pm - 4:15pm Gloria Sheynkman, PhD, University of Virginia An Integrated Functional Proteomics Platform for Accelerated Discovery of Isoform-Specific Determinants of Cancer
4:15pm - 4:30pm Neel H. Shah, PhD, and Andrew Johns, PhD candidate, Columbia University A Generalizable Photo-Crosslinking Strategy to Identify Tyrosine Phosphatase Substrates
4:30pm - 4:45pm Kristen M. Naegle, PhD, University of Virginia A Synthetic Toolkit for the Recombinant Production of Tyrosine Phosphorylated Proteins and Peptides
4:45pm - 5:00pm Kelly Crotty, PhD, National Cancer Institute Closing Remarks