Agenda

Sunday, November 30th
6:00pm - 8:00pm Networking Event - Three Notch'd Brewing Company. Please join anytime; food and drink for purchase in a reserved space for IMAT investigators and UVA invitees. 520 2nd St SE, Charlottesville, VA 22902

Monday, December 1st
9:00am - 9:15am Introduction/Welcome
9:15am - 9:45am Thomas P. Loughran Jr., MD, Director, UVA Comprehensive Cancer Center UVACCC Welcome and Overview
9:45am - 10:00am Jarrod Marto, PhD, University of Virginia UVA History of Innovation and Highlights
Session Preclinical Screening
Moderated By: Nan Liu, PhD
10:00am - 10:15am Guillem Pratx, PhD, Stanford University A Novel Assay to Individualize Resensitization of Iodine-Refractory Thyroid Cancer
10:15am - 10:30am Soma Dhakal, PhD, Virginia Commonwealth University Towards High-Confidence Single-Molecule Detection of miRNA Cancer Biomarkers
10:30am - 10:45am Joshua Labaer, MD, PhD, Arizona State University Multiplex In-Solution Protein Array (MISPA) for High-Throughput, Quantitative, Early Profiling of Pathogen-Induced Head and Neck Cancer
10:45am - 11:00am Coffee Break
11:00am - 11:15am Nir Hacohen, PhD, Harvard University RNA-Encoded Large-Scale Nanobody Libraries for In Vitro Screening Against Tumor Targets
11:15am - 11:30am Kate Meyer, PhD, Duke University A High-Throughput Screening Platform to Discover RNA Methylation Inhibitors
11:30am - 11:45am Flash Talks
• Yanxiang Deng, PhD, University of Pennsylvania: Spatially Resolved Multi-Omits Sequencing of FFPE Tissues at a Cellular Level;
• Jesse Boehm, PhD, MIT: Label-Free Morphological Profiling Enables Rapid Ex Vivo Evaluation of Anti-Cancer Drug Sensitivity in Gastroesophogeal Ascites;
• Tania (Tali) Konry, PhD, Northeastern University: Development of a Microfluidic MM-on-a-Chip Platform to Model Immunotherapy Resistance in a Hypoxic Tumor Microenvironment.
11:45am - 1:15pm Lunch
Session Clinical Session 1
1:15pm - 1:30pm Christopher M. Counter, PhD, Duke University KRAS Mutations in Whole Body Blood by Error-Corrected Sequencing
1:30pm - 1:45pm Steven A. Soper, PhD, the University of Kansas Molecular Sub-Typing Breast Cancer Patients Using a Liquid Biopsy
1:45pm - 2:00pm Eric J. Duncavage, MD, Washington University in St. Louis A Rapid and Comprehensive Approach for Clinical Genomic Profiling in Lung Cancer
2:00pm - 2:15pm David Aaron Issadore, PhD, University of Pennsylvania Combining Machine Learning and Nanofluidic Technology for the Multiplexed Diagnosis of Pancreatic Adenocarcinoma
2:15pm - 2:30pm Jose Javier Bravo-Cordero, PhD, Icahn School of Medicine at Mount Sinai Intersectional Genetics-Based Biosensors for Dormant Cancer Cells
2:30pm - 3:00pm Coffee Break
3:00pm - 3:20pm Xin Ma, PhD, University of Virginia (Guest) Evaluating Invasive Potentials of Pituitary Neuroendocrine Tumors Using High-Resolution Spatial Metabolomics
3:20pm - 3:40pm Kelsey Kubelick, PhD, University of Virginia (Guest) Echoing Immunotherapy — Ultrasound and Photoacoustic Imaging Towards Advanced Cancer Theranostics
3:40pm - 4:10pm Flash Talks
• Amanda Kussrow, PhD, Vanderbilt University: Quantification of Molecular Interactions Across the Matrix Spectrum Enables Cancer Research;
• Alberto Alaya Sarmiento, PhD, Cedars Sinai: Enabling In Vivo Barcoded Single-Cell Multiomics-Compatible Genome-Wide Screens in Personalized Tumor Models Using Defined-Copy Somatic Transgenesis;
• Huiqing (Jane) Zhou, PhD, Boston College: Development of a Directed Evolution Platform for RNA Methyltransferases;
• Matthew Shorey, PhD, Houston Methodist: A Multiplexed High-Throughput Platform to Report Pharmacologic Alteration of Cancer Stem Cell Membrane Potential and Cell Cycle States;
• Esther Mozipo, Stanford University: Tumor Metabolic Profiling by Multiplexed Single-Cell Lipid and mRNA Imaging.
4:10pm - 5:00pm Panel Discussion: Engage, support and cultivate successful team-based efforts
Moderated By: Adrian Shimpi, PhD, University of Virginia 		Panelists: David Kashatus, PhD, Kelly Shaffer, PhD, and Francine Garrett-Bakelman, MD, University of Virginia
5:00pm - 5:25pm Transition - Music Provided by Youth Orchestras of Central Virginia
5:25pm - 6:10pm Poster Session A
6:15pm - 7:00pm Poster Session B

Tuesday, December 2nd
9:00am - 9:10am Organizer updates/housekeeping
Session Clinical Session 2
Moderated By: Zhengyuan Pang, PhD
9:10am - 9:25am Abraham P. Lee PhD, University of California, Irvine Microfluidic Precision Engineered Artificial Antigen Presenting Cells for Cancer Immunotherapy
9:25am - 9:40am Sidi Chen, PhD, Yale University Advanced Development of Composite Gene Delivery and CAR Engineering Systems
9:40am - 9:55am Venktesh Shirure, PhD, University of California, Davis Microfluidic Technology to Isolate Tumoricidal T Cells from Peripheral Blood
9:55am - 10:10am Tianyi Zheng, PhD, University of Wisconsin-Madison Integrative Multi-Modal Analysis of Collagen Alterations in Cancer Models via SHG and Mid-IR Spectroscopy Imaging
10:10am - 10:25am Yevgeny Brudno, PhD, North Carolina State University Transduction Sponges for Rapid and Accessible CAR T-Cell Prototyping
10:25am - 10:45am Coffee Break
Session Sequencing and Biosensors
10:45am - 11:00am Wendy Gordon, PhD, University of Minnesota Twin Cities Engineering Protein Modulators of Notch Activation for T-Cell Immunotherapy
11:00am - 11:15am Hanlee P. Ji, MD, Stanford University Single Cell Modeling of Cancer Mutations
11:15am - 11:30am Rizal Hariadi, PhD, Arizona State University High-Throughput, Purification-Free, and Ultrasensitive Transmembrane Nanosensor Arrays for Digital Counting of MicroRNA Biomarkers of Intact Exosomes
11:30am - 11:50am Kristin Anderson, PhD, University of Virginia (Guest) Engineering Anti-Tumor Immunity to Effectively Treat Solid Tumors
11:50am - 1:20pm Lunch
Session Geospatial and Imaging
Moderated By: Vishal Srikanth, PhD
1:20pm - 1:35pm Jonathan Carlson, MD, PhD, Harvard University Bioorthogonal Probe Development for Highly Parallel In Vivo Imaging
1:35pm - 1:50pm Zhengyuan Pang, PhD. Scripps Research Institute Mapping Cellular Targets of Covalent Cancer Drugs in the Entire Mammalian Body
1:50pm - 2:05pm Connor Grady, PhD, University of Michigan Integrated Imaging Tools for Intercellular Chemokine Signalling
2:05pm - 2:20pm Facundo Martin Fernandez, PhD, Georgia Institute of Technology Triboelectric Nanogenerator-Powered Laser Ablation Electrospray Ionization (TENG LAESI) Mass Spectrometry Imaging Ion Source
2:20pm - 2:35pm Peter van Galen, PhD, Harvard University Clonal Analysis of Cancer by Mitochondrial DNA Barcoding
2:35pm - 2:55pm Jinghang Xie, PhD, Universty of Virginia (Guest) From Biospecimens to Living Drugs: Functional T-Cell Imaging to Enhance Tumor Infiltrating Lymphocyte Therapy
2:55pm - 3:10pm Coffee Break
3:10pm - 4:00pm Panel Discussion: Building and Finding Ecosystems for Innovation and Translation
Moderated By: Kelly Crotty, PhD, NCI 		Panelists: Nikki Hastings, PhD, Director, CvilleBioHub, Evan Scott, PhD, Director, NanoSTAR, University of Virginia, and David Chen, MS MBA, Director Coulter Center for Translational Research
Session Protein Engineering and Detection
4:00pm - 4:15pm Gloria Sheynkman, PhD, University of Virginia An Integrated Functional Proteomics Platform for Accelerated Discovery of Isoform-Specific Determinants of Cancer
4:15pm - 4:30pm Neel H. Shah, PhD, and Andrew Johns, PhD candidate, Columbia University A Generalizable Photo-Crosslinking Strategy to Identify Tyrosine Phosphatase Substrates
4:30pm - 4:45pm Kristen M. Naegle, PhD, University of Virginia A Synthetic Toolkit for the Recombinant Production of Tyrosine Phosphorylated Proteins and Peptides
4:45pm - 5:00pm Kelly Crotty, PhD, National Cancer Institute Closing Remarks